npr: Gangs mix another potent sedative into U.S. street drugs causing 'mass overdoses'
Public health officials say Mexican cartels and drug gangs inside the U.S. are mixing a dangerous chemical sedative called medetomidine into fentanyl and other drugs sold on the street. The combination triggered a new wave of overdoses that began in late April and have accelerated in May.
Aug 8
"The numbers reported out of Philadelphia were 160 hospitalizations over a 3 or 4-day period," said Alex Krotulski who heads an organization called NPS Discovery that studies illicit drugs sold in the U.S. Medetomidine, most often used by veterinarians as an animal tranquilizer, but also formulated for use in human patients, has also been linked to a recent “mass overdose outbreaks in Chicago.
Preliminary data also suggested another mass overdose event linked to medetomidine in Pittsburgh, but those initial findings proved false, according to Krotulski. Experts say the chemical, mixed into counterfeit pills and powders sold on the street, slows the human heart rate to dangerous levels. It's impossible for drug users to detect.
Public health advisories have been issued in Illinois and Pennsylvania. Dr. Brendan Hart at Temple University in Philadelphia says they first began hearing reports of street drug users exposed to the fentanyl-medetomidine mix in April. "Some of our emergency medicine doctors started stopping me in the hallway," Hart told NPR.
"They said 'Something funny is going on with the overdoses.' Patients were coming in with very low heart rates. As low as in the 20s. A normal heart-rate is sixty to a hundred [beats per minute] so 20s is extremely low."
Laboratory tests of street drug samples came back positive for the powerful sedative, which is used in some formulations by doctors with human patients, but only in carefully controlled medical settings. Medetomidine was previously detected in the illicit drug supply as early as 2022 but only rarely and in small amounts. This time experts say it appears to be spreading rapidly, with large-scale overdose events also reported earlier this year in Toronto, Canada.
U.S. drug supply grows more toxic
Laboratory tests of street drug samples came back positive for the powerful sedative, which is used in some formulations by doctors with human patients, but only in carefully controlled medical settings. Medetomidine was previously detected in the illicit drug supply as early as 2022 but only rarely and in small amounts. This time experts say it appears to be spreading rapidly, with large-scale overdose events also reported earlier this year in Toronto, Canada.
U.S. drug supply grows more toxic
Last year the Biden administration issued a warning that street fentanyl was being mixed with another tranquilizer used by veterinarians called xylazine. That mix of drugs led to more overdoses and many users also experience terrible flesh wounds that can linger for months or years.
Medetomidine is even more powerful than xylazine, experts told NPR. As it spreads, Krotulski said no one knows what long-term health effects this new cocktail of chemicals will cause in the human body.
"Patients are being cared for as we speak in emergency rooms," he said. "These are very complex drug products. You’ve got fentanyl adulterated with xylazine that now also contains medetomidine."
The presence of these chemical additives severely complicates the medical response to high-risk overdoses.
The presence of these chemical additives severely complicates the medical response to high-risk overdoses.
Xylazine and medetomidine don't respond to naloxone, the medication used to reverse most fentanyl overdoses. There’s currently no way for street users to know when their drugs are laced with this chemical.
Dr. Bertha Madras, a drug researcher at Harvard Medical School and McLean Hospital, said it’s not clear why drug gangs are mixing these new chemicals with fentanyl. Some experts believe sedatives may prolong the opioid high, making the drugs more desirable on the street.
According to Madras, it's urgent that first responders and emergency rooms be prepared to treat overdoses complicated by heart conditions triggered by medetomidine.
She also thinks people using drugs need to be warned that illicit pills and powders are more perilous than ever.
"It’s critical to alert street users," Madras said. "They’re playing Russian roulette now with the drug supply."
Madras said experts are also working to understand where the medetomidine appearing on U.S. streets is coming from.It's not yet clear whether the sedative is being illegally diverted from veterinarian supplies or from medications intended for use in hospitals and clinics.
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